Researchers Identify New Role for Cytokine VEGFA in the Metastasis of Neuroblastoma

Some really great research going on at Children’s Hospital Los Angeles and the University of Southern California.

Expression of mVEGFA in bones injected with human CHLA-255 NBL cells. H&E stain of a section through a femur three weeks postinjection with CHLA-255 cells in the BM cavity (upper left). NBL cells were detected with an anti-TH antibody (upper right). Detail of a tumor nodule outlined in red (lower left). Immunohistochemistry on an adjacent section with an antimouse VEGFA antibody, positive cells from the host tissue are surrounding the tumor (lower middle). Detail showing VEGFA-positive cells in close proximity of the bone and surrounding the tumor border (lower right). B: bone; T: tumor; GP: growth plate. Scale bar = 50 μm.  Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis.  Sposto et al 2015.

Healthy bone is continuously involved in a dynamic process that includes bone deposition and bone resorption. However, when a person has cancer that spreads to the bone and bone marrow, the tissue becomes increasingly fragile, and this process is disrupted, usually leading to increased bone resorption. Now investigators at Children’s Hospital Los Angeles and the University of Southern California reported a surprising discovery, when neuroblastoma cells metastasize to the bone, there initially occurs an increase in bone deposition, not resorption. They also determined that this process is driven by a chemical messenger called VEGFA.  The study is published in the International Journal of Cancer. Neuroblastoma is the most common extra-cranial solid tumour occurring during childhood and frequently metastasizes to the bone and bone marrow, making the disease more difficult for doctors to treat and conferring a worse prognosis for patients. Teams of scientists have been working to determine what causes a tumour to metastasize, knowing it is an interaction between tumour cells and the metastatic site, called the microenvironment.

Please follow this link to read the  full article in Health Innovations


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This is a blog about CHILDHOOD CANCER and CHILDHOOD CANCER AWARENESS Little Fighters Cancer Trust is a non-profit organisation that offers support and aid to Children with Cancer and their families. When a child is diagnosed with cancer it affects the whole family. One of the parents, usually the mother, must give up their job to care for the child and this creates financial problems for the family. In South Africa especially the majority of these families are not well-to-do; many of them are rural. A diagnosis of cancer can wipe out any family’s finances, let alone a poor family. The costs of special medications, special diets, hospital stays, transport to and from the hospital or clinic and accommodation and food costs for the mother who spends most of the time at her child’s bedside are astronomical. These are the people and problems that fall through the cracks, and these are the people that Little Fighters Cancer Trust has pledged to help in any way possible. LFCT takes a holistic approach to assisting the Children with Cancer and their Families, with the main aim to be the preservation of individual dignity and pride. Little Fighters Cancer Trust also focuses on promotion and advocacy of National Childhood Cancer Awareness in an effort to increase awareness of Early Warning Signs of Childhood Cancer. This would result in earlier diagnosis, giving the Child with Cancer more of a chance at Treatment and Survival. See "About" for more Background info

Posted on 19 March, 2015, in Blog, Research and tagged , , , , , . Bookmark the permalink. Leave a comment.

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