Selective mitochondrial chemotherapy, decimates brain tumours and headed for human trials
An experimental drug that attacks brain tumour tissue by crippling the cells’ energy source called the mitochondria has passed early tests in animal models and human tissue cultures, state researchers Houston Methodist and Weill Cornell Medical College. The team designed a drug called MP-MUS that destroyed 90 to 95 percent of malignant glioma cells, yet in other experiments did not seem to adversely affect healthy human brain cells (in vitro). This compliments a soon to be published extensive study showing the same drug can treat human brain cancer grown in the brains of mice. Researchers hope to begin testing the drug in human clinical trials in 2016. The study is published in the journal ChemMedChem.
Previous studies from the lab have shown that MP-MUS has very low toxicity until it gets into tumour cells. Once it arrives, it is changed to its active form, doing a lot of damage to cancer cells selectively, leaving healthy brain cells alone. To the team’s knowledge, this is the first known example of selective mitochondrial chemotherapy, which they believe represents a powerful new approach to brain cancer.
Read the Full Article on Health Innovations
Posted on 24 May, 2015, in Blog, Brain Cancer and tagged brain cancer, brain cancer awareness, brain cancer awareness month, brain tumor, brain tumours, childhood brain cancer, Childhood Cancer Awareness, LFCT, Little Fighters Cancer Trust. Bookmark the permalink. Leave a comment.