Fat Cells Originating from Bone Marrow Linked to Cancer?


2000px-Gray72-smResearchers at the University of Colorado Anschutz Medical Campus have found that fat cells produced by stem cells from the bone marrow may be linked to chronic illnesses like diabetes, cardiovascular disease, kidney disease and some cancers.

It has always been assumed that fat-storing cells are produced only from stem cells that live and self-renew in fat tissue,” said the study’s senior author Dwight Klemm, PhD, professor of medicine at the University of Colorado School of Medicine. “But our paper, along with one recently published by our colleagues in Sweden, shows for the first time fat cells produced by stem cells that originate in the bone marrow inside human fat tissue.”

The study found that a significant number of fat cells are generated from bone marrow stem cells.

That’s important, Klemm said, because previous studies in mice have shown that these cells produce substances called cytokines, which promote inflammation and hinder the ability of other cells to respond to insulin, increasing the risk for diabetes.

“Our study suggests that it may be the type of fat-storing cell produced in our bodies that determines risk for disease, rather than the amount of fat,” said Klemm, an expert on obesity and pulmonary hypertension. “This discovery highlights the possibility of new strategies to prevent and reverse fat-related chronic diseases by controlling the production of different types of fat-storing cells.

The study was done using people who had received a bone marrow transplant from another donor. A small sample of their fat tissue was removed from just under the skin. The DNA from those fat cells was evaluated to determine if it came from the person who donated the bone marrow or the recipient.

“We detected the presence of donor DNA, which indicated that some of the fat cells had grown from cells that originated in the transplanted bone marrow,” said Kathleen Gavin, PhD, postdoctoral fellow and lead author on the study.

If researchers can show that these cells are linked to chronic diseases, they may be able to genetically modify and ultimately block their production, part of CU Anschutz’s commitment to taking advances in research from the laboratory to the clinic.

Klemm believes it’s possible to prevent or reverse fat-related chronic disease by controlling the type of fat-storing cells produced in the body.

“Even more exciting is the possibility of combining bone marrow or stem cell transplant technology with genetic engineering to tailor-make fat-storing cells with specific desirable functions,” he said, stressing the importance of collaborative research in bringing the best new treatments to patients. “By preventing the production of harmful fat cells it may be possible to prevent or reverse fat-related chronic disease, even without weight loss.”

The study was published in the latest Journal of the Federation of American Societies for Experimental Biology.

The other authors include Kathleen Gavin, PhD, Jonathan Gutman, MD, Wendy Kohrt, PhD and Karen Shea, MD, all from CU Anschutz.

 

Source: MNT

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This is a blog about CHILDHOOD CANCER and CHILDHOOD CANCER AWARENESS Little Fighters Cancer Trust is a non-profit organisation that offers support and aid to Children with Cancer and their families. When a child is diagnosed with cancer it affects the whole family. One of the parents, usually the mother, must give up their job to care for the child and this creates financial problems for the family. In South Africa especially the majority of these families are not well-to-do; many of them are rural. A diagnosis of cancer can wipe out any family’s finances, let alone a poor family. The costs of special medications, special diets, hospital stays, transport to and from the hospital or clinic and accommodation and food costs for the mother who spends most of the time at her child’s bedside are astronomical. These are the people and problems that fall through the cracks, and these are the people that Little Fighters Cancer Trust has pledged to help in any way possible. LFCT takes a holistic approach to assisting the Children with Cancer and their Families, with the main aim to be the preservation of individual dignity and pride. Little Fighters Cancer Trust also focuses on promotion and advocacy of National Childhood Cancer Awareness in an effort to increase awareness of Early Warning Signs of Childhood Cancer. This would result in earlier diagnosis, giving the Child with Cancer more of a chance at Treatment and Survival. See "About" for more Background info

Posted on 27 November, 2015, in Blog, Research. Bookmark the permalink. Leave a comment.

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