New Research Suggests a Novel Route in the Fight against Cancer


strand of DNA providing directions for transcription of mRNAIn a new study published in Nature Structural and Molecular Biology, scientists from the University of Surrey have uncovered a collection of important proteins that carry out and regulate critical biological processes.

As the malfunctioning of these proteins and processes are linked to diseases such as cancer, their findings could help with the development of more effective therapies for treating incurable and debilitating illnesses.

In the study, the team provide the first comprehensive insight into an important class of regulatory proteins, RNA-binding proteins, and their interaction with the molecule mRNA – an important molecule that guides the synthesis of proteins – in two living organisms, baker’s yeast and roundworms.

Though these two organisms are very different, the scientists found a striking evolutionary conservation in the proteins they uncovered, suggesting new functions for metabolic enzymes, which the team believes has remained in existence for billions of years.

This is an important breakthrough as the proteins and processes we have identified are also present in humans, and we know they have strong links to diseases such as cancer and neurodegenerative diseases. Now we can use our new knowledge to test whether this is the case – a new mechanism for controlling key biological processes could eventually lead to the development of effective cancer treatments,” said lead author Professor André Gerber from the University of Surrey

It could be that the RNA is driving the function, harking back to ancient mechanisms, before proteins were on the scene, or it could be that the proteins have a hidden function that we didn’t know about,” added co-author, Dr Emma Laing from the University of Surrey.

 

More Information: Conserved mRNA-binding proteomes in eukaryotic organisms, Nature Structural and Molecular Biology, DOI: 10.1038/nsmb.3128

Journal Reference: Nature Structural and Molecular Biology

Provided By: University of Surrey

 

 

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About LFCT

This is a blog about CHILDHOOD CANCER and CHILDHOOD CANCER AWARENESS Little Fighters Cancer Trust is a non-profit organisation that offers support and aid to Children with Cancer and their families. When a child is diagnosed with cancer it affects the whole family. One of the parents, usually the mother, must give up their job to care for the child and this creates financial problems for the family. In South Africa especially the majority of these families are not well-to-do; many of them are rural. A diagnosis of cancer can wipe out any family’s finances, let alone a poor family. The costs of special medications, special diets, hospital stays, transport to and from the hospital or clinic and accommodation and food costs for the mother who spends most of the time at her child’s bedside are astronomical. These are the people and problems that fall through the cracks, and these are the people that Little Fighters Cancer Trust has pledged to help in any way possible. LFCT takes a holistic approach to assisting the Children with Cancer and their Families, with the main aim to be the preservation of individual dignity and pride. Little Fighters Cancer Trust also focuses on promotion and advocacy of National Childhood Cancer Awareness in an effort to increase awareness of Early Warning Signs of Childhood Cancer. This would result in earlier diagnosis, giving the Child with Cancer more of a chance at Treatment and Survival. See "About" for more Background info

Posted on 1 December, 2015, in Blog, Research and tagged . Bookmark the permalink. 1 Comment.

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