Artificial Intelligence Reveals Mechanism behind Brain Tumour


brain-cancerResearchers at Uppsala University have used computer modelling to study how brain tumours arise.

The study, which was published recently in the journal EBioMedicine, illustrated how researchers in the future will be able to use large-scale data to find new disease mechanisms and identify new treatment targets.

The last ten years’ progress in molecular biology has drastically changed how cancer researchers work. Instead of almost exclusively using different biological models, like cells, today large-scale statistical analyses are increasingly used to understand tumour diseases and find new therapies.

Researchers at Uppsala University, together with colleagues at the University of Gothenburg, Chalmers University of Technology and University of Freiburg, have developed a new algorithm, aSICS, that uses large amounts of data to suggest hypotheses about “what causes what” in a cancer cell.

Researchers used aSICS to interpret data from brain tumours and they could identify a new mechanism behind mesenchymal glioblastoma, an extra aggressive brain tumour type.

“According to the computer model, mesenchymal glioblastoma is partly caused by alterations in a gene called Annexin A2. To validate the relevance of this prediction we examined samples from patients and could show that mesenchymal glioblastoma have an increased activity of Annexin A2. Subsequently, we tested to inhibit the expression of Annexin A2 in cancer cells from patients and found that the cancer cells either died or changed to a less aggressive form‘, says Sven Nelander at the Department of Immunology, Genetics and Pathology at Uppsala University,’ who has led the study together with a colleague in Freiburg.

The results show that data analyses can be used to predict which genes or proteins influence the development of a tumour, and then confirm the prediction with experiments in the lab.

The aSICS method has also been tested on other kinds of cancer, with promising results, although further studies are needed to fine-tune the settings.

 

Advertisements

About LFCT

This is a blog about CHILDHOOD CANCER and CHILDHOOD CANCER AWARENESS Little Fighters Cancer Trust is a non-profit organisation that offers support and aid to Children with Cancer and their families. When a child is diagnosed with cancer it affects the whole family. One of the parents, usually the mother, must give up their job to care for the child and this creates financial problems for the family. In South Africa especially the majority of these families are not well-to-do; many of them are rural. A diagnosis of cancer can wipe out any family’s finances, let alone a poor family. The costs of special medications, special diets, hospital stays, transport to and from the hospital or clinic and accommodation and food costs for the mother who spends most of the time at her child’s bedside are astronomical. These are the people and problems that fall through the cracks, and these are the people that Little Fighters Cancer Trust has pledged to help in any way possible. LFCT takes a holistic approach to assisting the Children with Cancer and their Families, with the main aim to be the preservation of individual dignity and pride. Little Fighters Cancer Trust also focuses on promotion and advocacy of National Childhood Cancer Awareness in an effort to increase awareness of Early Warning Signs of Childhood Cancer. This would result in earlier diagnosis, giving the Child with Cancer more of a chance at Treatment and Survival. See "About" for more Background info

Posted on 30 September, 2016, in Blog, Research and tagged , , , , , , . Bookmark the permalink. Leave a comment.

Please help us to Raise Childhood Cancer Awareness by Commenting and Sharing

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

My Name is Chuma

a blog from a Cape Town inner city artist

Knitting Rays of Hope

Spreading Hope...a hat at a time.

The Starlit Path

An African Travelling Under Starry Skies

Soul Gatherings

Spiritual Moments in the Human Experience

lovehopeandcourage

Inspired by ordinary people doing extraordinary things

Surviving The Bubble

Jamie Hutchings, Public speaker, leukemia survivor and depression fighter

beingmommie.com

Sharing my learnings of being a mother

Art of Social Work

Kristina Sargent

How to Provide

for your family

%d bloggers like this: