Cancer Patients Should Avoid CHOCOLATE
According to recent research from the Institute for Research in Barcelona, funded by Worldwide Cancer Research, eating chocolate, biscuits and bread while suffering from cancer makes the disease more deadly.
A key ingredient in palm oil,found in some toiletries and in various foodstuffs, including chocolate, stimulates a protein called CD36 in humans.
This protein, which is found in the membranes of tumour cells, is responsible for taking up fatty acids. CD36 activity and dependence on lipid (fat) metabolism distinguish metastasis-initiating cells from other tumour cells.
Experts believe that this protein plays a vital role in tumours spreading around the body (metastasising), making it more deadly. It is hoped the ‘game-changing’ findings could lead to new treatments to prevent cancer from reaching vital organs.
Spanish researchers found the protein in the membranes of tumour cells taken from patients with advanced mouth, skin, ovarian, bladder, lung and breast cancers. In animal studies, it was found that those whose cancer was exposed to CD36 went on to develop metastasis, according to the study, which was published in the journal Nature. Only half of those without ended up having their tumours metastasise, the team found.
Further research showed that blocking the protein with antibodies completely prevented metastasis in mice; while in mice whose cancer had already spread, disease progress was halted by one fifth. Researchers are now working on developing antibody-based therapies that target CD36 that work specifically on humans.
IRB Barcelona: Targeting metastasis-initiating cells through the fatty acid receptor CD36
Published on Dec 7, 2016
A two-minute animation that explains the discovery published in Nature magazine (07/12/2016). The study shows that tumour cells are dependent on fat to start metastasis.
According to Lead Researcher, Salvador Aznar Benitah, ICREA researcher at the Institute for Research in Biomedicine (IRB Barcelona):
“In mice inoculated with human tumour cells, there appears to be a direct link between fat intake and an increase in metastatic potential through CD36. It is hoped the ‘game-changing’ findings could lead to new treatments to prevent cancer from reaching vital organs. More studies are needed to unravel this intriguing relationship, above all because industrialised countries are registering an alarming increase in the consumption of saturated fats and sugar.”
“Fat is necessary for the function of the body, but uncontrolled intake can have an effect on health, as already shown for some tumours such as colon cancer, and in metastasis, as we demonstrate here.”
Dr Lara Bennett, Science Communications Manager at Worldwide Cancer Research said:
“We have been supporting Professor Benitah’s work for a number of years and it is fantastic to now see these truly game-changing results. If the team are able to go on to develop this antibody into a treatment for humans, it could save thousands of lives every year.”
Posted on 19 December, 2016, in Blog, Research, Videos and tagged cancer, cancer cells, cancer research, cancer treatment, CD36, childhood cancer, Pediatric cancer. Bookmark the permalink. Leave a comment.