Why do Some Children Develop Brain Tumours?

Any time a child is diagnosed with a brain tumour or, truth be told, any type of cancer, the most obvious question many parents ask is “Why? What caused my child to develop a brain tumour?”

Unfortunately, there is no easy answer to this question.

Scientists now believe that the vast majority of brain tumours in children are the result of random gene mutations but have no satisfying answer as to why a particular gene mutation occurred or why it led to the growth of a brain tumour.

Whether benign or malignant, a tumour grows when certain cells grow, divide, and replicate more quickly than normal cells and/or they do not die when they are aged or damaged. These abnormal cells then begin to build up in the brain, forming clumps or a mass, and eventually growing large enough to press on or cause damage to the healthy brain tissue.

So why do some cells grow, function, and die normally, while others grow abnormally and develop into a brain tumour? Scientists currently believe that these abnormal cells are the result of mutations (random changes) within the DNA in each cell.

Mutations in oncogenes inhibit when cells grow and divide properly, while mutations in tumour suppressor genes prevent cells from slowing their rate of replication and prevent them from dying at the proper time.

Because mutations are a natural part of the lifecycle of our cells—occurring frequently as our cells grow and divide over time—preventing or predicting these mutations is currently impossible.

Risk Factors for Brain Tumours in Children

A “risk factor” is anything that increases a child’s risk of developing a brain tumour. As stated above, scientists believe that the vast majority of cases of childhood brain tumours are caused by random gene mutations.

Gene mutations are a natural part of human biology and usually do not have a specific or identifiable cause. Therefore, there are very few known risk factors linked to the development of brain tumours in children, with two notable exceptions:

  • Radiation exposure: Exposure to large amounts of radiation has been linked to several types of cancer, including brain tumours in children. While low-level radiation exposure is an accepted aspect of today’s medical care (x-rays, for instance, for dental treatment or to diagnose a broken bone), the medical community goes to great lengths to protect children from high dosages of radiation exposure.

However, radiation therapy has proven to be an effective tool when fighting some types of cancer. While most oncologists will limit or avoid altogether the use of radiation when treating very young children, in some cases, the benefits of treating the immediate threat posed by cancer must be weighed against the potential risk of developing a brain tumour or other secondary cancer in the future.

  • Inherited genetic conditions: In a very small number of cases (less than 5%), children have an inherited genetic condition that might potentially increase the risk of developing a brain tumour. Although these conditions themselves are very, very rare, some have been linked to an elevated risk for brain tumours:
  • Neurofibromatosis type 1 (von Recklinghausen disease)
  • Neurofibromatosis type 2
  • Von Hippel-Lindau disease
  • Tuberous sclerosis
  • Gorlin syndrome (basal cell nevus syndrome)
  • Li-Fraumeni syndrome
  • Turcot syndrome
  • Hereditary retinoblastoma
  • Cowden syndrome
  • Rubinstein-Taybi syndrome


Can We Prevent a Brain Tumour?

Unfortunately, all too many parents—after hearing that their child has been diagnosed with a brain tumour—feel an overwhelming sense of guilt. Many wonder whether this diagnosis is somehow their fault, or whether they might have been able to do something to prevent this diagnosis.

However, any oncologist will assure these parents that there is absolutely nothing they could have done to prevent their child from developing a brain tumour.

Brain tumours in children are not believed to be linked to any environmental factors or lifestyle choices (with the notable exception of radiation exposure noted above); instead, they are most likely the result of random and uncontrollable gene mutations.


About LFCT

CHILDHOOD CANCER and CHILDHOOD CANCER AWARENESS Little Fighters Cancer Trust is a non-profit Childhood Cancer support organisation that offers support and aid to Children with Cancer and their families. When a child is diagnosed with cancer it affects the whole family. One of the parents, usually the mother, must give up their job to care for the child and this creates financial problems for the family. In South Africa especially the majority of these families are not well-to-do; many of them are rural. A diagnosis of cancer can wipe out any family’s finances, let alone a poor family. The costs of special medications, special diets, hospital stays, transport to and from the hospital or clinic and accommodation and food costs for the mother who spends most of the time at her child’s bedside are astronomical. These are the people and problems that fall through the cracks, and these are the people that Little Fighters Cancer Trust has pledged to help in any way possible. LFCT takes a holistic approach to assisting the Children with Cancer and their Families, with the main aim to be the preservation of individual dignity and pride. Little Fighters Cancer Trust also focuses on promotion and advocacy of National Childhood Cancer Awareness in an effort to increase awareness of Early Warning Signs of Childhood Cancer. This would result in earlier diagnosis, giving the Child with Cancer more of a chance at Treatment and Survival. See "About" for more Background info

Posted on 12 October, 2018, in Blog, Brain Cancer and tagged , , , , , , . Bookmark the permalink. Leave a comment.

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