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Chemobrain in Childhood Cancer


23843263_sSymptom Management, Palliative Care, or Supportive Care to relieve side-effects is an important part of cancer care and treatment and should always form part of the  overall treatment plan.

Around 70% of cancer survivors report difficulties with memory and concentration after undergoing chemotherapy – this is conversationally referred to as “Chemobrain,” which is described as a mental clouding or fogginess, during and after cancer treatment.

Chemobrain refers to the cognitive impairment that can occur after cancer treatment. It’s not limited to people who undergo chemotherapy (surgery and radiation can also contribute), but it’s more noticeable if one has undergone chemotherapy.

Doctors used to dismiss patients who complained of brain fog after cancer treatment. It’s still unclear exactly how many patients among the 15-million-plus cancer survivors are affected.

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Anti-Cancer Immunity Boosted by Newly Created Compound


Scientists might have found a way to activate the body’s “natural killer T cells” in the fight against cancer. The findings might lead to more effective treatments that stop cancer from spreading.

A  new study, Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity which has recently been published in the journal Cell Chemical Biology — was led by chemistry professor Amy Howell, from the University of Connecticut in Mansfield.

Prof. Howell and her team sought a compound that would activate human immune cells called Invariant natural killer T (iNKT) cells for any years.

iNKT cells give our immune system crucial ammunition in the fight against infections but also against illnesses such as cancer, lupus, and multiple sclerosis.

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👦 Update On Little Fighter KENZO 👦


Little Fighter Kenzo Phillips was diagnosed with Acute Lymphoblastic Leukaemia (ALL) in February 2016, at a mere 8 months of age.

Kenzo has gone through much in his short lifespan, including harsh chemotherapy treatments, and has seen more hospitals and doctors than any child should…

Earlier this month LFCT celebrated with Kenzo and his family at the news that, after his annual 4 weekly check-up – a full month after his final chemo treatment – His blood counts were perfect and the doctors were very happy – his Bone Marrow Biopsy also came back CLEAR!!!!!

Cancer is fickle however, and a mere FIVE DAYS later Kenzo was rushed to hospital with a terrible headache & vomiting.

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Immunotherapy May Help Stop Cancer Recurrence


Cancer can never really be “cured” – one just goes into “remission” because the cancer can come back at any time, and when it does it is generally a far worse strain.

Cancer Survivors live their lives knowing that they have this “time-bomb” inside of them that may go off again at any time, and that there is absolutely nothing that they can do about it – one just lives with the constant fear of recurrence.

New research by Mayo Clinic’s Tim Kottke and his team, which was recently published in the journal Cancer Immunology Research, may hold some hope though.

The new research was a collaborative effort among scientists at the Institute of Cancer Research in London, the Leeds Institute of Cancer and Pathology, and the University of Surrey in Guildford — all of which are in the United Kingdom — and researchers from the Mayo Clinic in Rochester, MN.

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Why Are Childhood Cancer Rates on the Rise?


Global childhood cancer rates jumped 13% in the decade to 2010 compared to the 1980s, according to a UN-backed study that says the increase may be due in part to improved detection.

For children under 15, the incidence rate of cancer was 140 per million during the first decade of this century, the International Agency for Research on Cancer (IARC) reported in The Lancet Oncology.

Locally, the Cancer Association of South Africa (CANSA) in a previous review stated that many developing countries are going through rapid societal and economic changes, and there is a shift toward lifestyles representative of industrialised countries. These factors, along with changes in reproductive, dietary, and hormonal risk factors, are contributing to the rising cancer rates.

Ty Bollinger lost both his mother and father to cancer (as well as 5 other family members). Ty travels the globe and sits down with the foremost doctors, researchers, experts, and cancer conquerers to find out their proven methods for preventing and treating cancer.

In this video, Ty speaks with the founder of the Dr. Rath Research Institure, Dr. Matthias Rath and the director of research, Dr. Aleksandra Niedzwiecki, about why childhood cancer rates are on the rise.

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Cancer Protects Itself via Inflammatory Pathways


A few years ago, scientists in the laboratory of Stanford’s Irving Weissman, MD, discovered that cancer cells cover themselves in copies of the CD47 “don’t eat me” protein to protect themselves from being engulfed and devoured by immune cells called macrophages.

What they could never really tell though, is how the cancer cells actually increased the production of CD47.

Recently, however, Weissman and his colleagues discovered that cancer cells accomplish this trick by recruiting molecular pathways usually used for inflammatory processes. One particular pathway involves a protein called tumour necrosis factor (TNF-alpha), which is produced in response to infection or trauma. It attracts and activates macrophage cells, which destroy sick or damaged cells. Ironically, that same genetic machinery is being used by cancer cells to protect themselves from those macrophages. The research study was published in the journal Nature Communications. Read the rest of this entry

Cancer-Detecting Gum May Soon Be Available: Fact or Fiction?


On April 10, 2017, Fox News published an article, Chew on this: Cancer-Detecting Gum May Soon Be Available, which stated that “soon there may be a new chewing gum that could help save your life.”

The article went on to say:

The gum absorbs what are known as “volatiles” in a person’s saliva as they chew it, then the chewed gum is analyzed to determine whether it contains certain chemicals produced in the body when a person has cancer.

Katherine Bazemore, president and CEO of Volatile Analysis explained that there are chemicals produced in the body called volatile organic compounds, and they are unique to each type of cancer. By determining which of those compounds are found in the gum, doctors can tell which type of cancer is present in the patient.

The gum is still in the testing stage so it may be too early to determine how well it will work. But the company is hoping to make the gum available to doctors and patients sometime next year.

While you may not be able to blow bubbles with it, Bazemore promises the gum will come in flavors that taste just like candy.

Now this sounds FANTASTIC, but is it the truth?

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Cancer Benefits of Cardamom


health-benefits-of-cardamomCardamom is a peppery, citrusy spice that is native to the evergreen forests of India and is commonly used in Indian cuisine, but it has also made its way into Ayurvedic medicine as a treatment for mouth ulcers, digestive problems, and even depression.

According to various studies, cardamom also contains cancer-fighting compounds with the potential to kill cancer cells as well as stunt new cancer cell growth. In India, Cardamom was known as the “Queen of spices” to black pepper’s title as the “King of spices”. Also in India, during the 11th century, it was listed as one of the ingredients in the “Five fragrance betel chew” in the Book of Splendour.

Historically, spices have shaped many events throughout the world. Many voyagers, including the legendary Christopher Columbus, explored the seas in search of treasured spices. These valued commodities contribute not only flavours but also serve as colorants and preservatives in a wide variety of cultures.

In Ayurveda (the ancient Indian science of medicine and lifestyle) and Traditional Chinese Medicine, cardamom was believed to be a remedy for teeth and gum infections, throat problems, congestion of the lungs, pulmonary tuberculosis, inflammation of the eyelids, gastrointestinal disorders, disintegrating kidney, and gall bladder stones, and was also used as an antidote for poisons and venoms.

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Direct-To-Brain Chemo Better Than Systemic Drugs When Immunotherapy Is To Follow


glioblastomaIn a recent study, Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM, researchers at Johns Hopkins have found in experiments on mice with a form of aggressive brain cancer, that localised chemotherapy delivered directly to the brain rather than given systemically may be the best way to keep the immune system intact and strong when immunotherapy is also part of the treatment.

The researchers say their study results, reported in Science Translational Medicine, could directly affect the design of immunotherapy clinical trials and treatment strategies for people with a deadly form of brain cancer called glioblastoma.

We understand that our research was done in a mouse model and not in humans, but our evidence is strong that systemic chemotherapy alters the immune system in a way that it never fully recovers,” says Michael Lim, M.D., associate professor of neurosurgery and director of brain tumor immunotherapy at the Johns Hopkins University School of Medicine, and member of the Johns Hopkins Kimmel Cancer Center.

With aggressive cancers like glioblastoma, it is important that we don’t handicap the defenses we may need to add alternative treatments, such as immunotherapy, to chemotherapy,” he adds.

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Graphene used to Detect Cancer Cells


graphene-graphicBy interfacing brain cells onto graphene, researchers at the University of Illinois at Chicago have shown they can differentiate a single hyperactive cancerous cell from a normal cell, pointing the way to developing a simple, non-invasive tool for early cancer diagnosis.

“This graphene system is able to detect the level of activity of an interfaced cell,” says Vikas Berry, associate professor and head of chemical engineering at UIC, who led the research along with Ankit Mehta, assistant professor of clinical neurosurgery in the UIC College of Medicine.

Graphene is the thinnest known material and is very sensitive to whatever happens on its surface,” Berry said. The nanomaterial is composed of a single layer of carbon atoms linked in a hexagonal chicken-wire pattern, and all the atoms share a cloud of electrons moving freely about the surface.

The cell’s interface with graphene rearranges the charge distribution in graphene, which modifies the energy of atomic vibration as detected by Raman spectroscopy,” Berry said, referring to a powerful workhorse technique that is routinely used to study graphene.

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